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( A ) PCA of global <t>transcriptomic</t> differences. ( B ) Heatmap of globally DEGs when modeled as ~ PDX_ID + RTS. ( C ) Volcano plot of globally DEGs when modeled by ~RTS alone (red text meets cutoffs of log 2 fold change > 2 or < –2, adjusted P < 0.05). ( D ) Circos plot of differentially regulated lncRNAs (red) with their direct DNA binding targets (black) and differentially regulated lncRNAs (blue) with their DNA binding sites.
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( A ) PCA of global <t>transcriptomic</t> differences. ( B ) Heatmap of globally DEGs when modeled as ~ PDX_ID + RTS. ( C ) Volcano plot of globally DEGs when modeled by ~RTS alone (red text meets cutoffs of log 2 fold change > 2 or < –2, adjusted P < 0.05). ( D ) Circos plot of differentially regulated lncRNAs (red) with their direct DNA binding targets (black) and differentially regulated lncRNAs (blue) with their DNA binding sites.
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( A ) PCA of global <t>transcriptomic</t> differences. ( B ) Heatmap of globally DEGs when modeled as ~ PDX_ID + RTS. ( C ) Volcano plot of globally DEGs when modeled by ~RTS alone (red text meets cutoffs of log 2 fold change > 2 or < –2, adjusted P < 0.05). ( D ) Circos plot of differentially regulated lncRNAs (red) with their direct DNA binding targets (black) and differentially regulated lncRNAs (blue) with their DNA binding sites.
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( A ) PCA of global <t>transcriptomic</t> differences. ( B ) Heatmap of globally DEGs when modeled as ~ PDX_ID + RTS. ( C ) Volcano plot of globally DEGs when modeled by ~RTS alone (red text meets cutoffs of log 2 fold change > 2 or < –2, adjusted P < 0.05). ( D ) Circos plot of differentially regulated lncRNAs (red) with their direct DNA binding targets (black) and differentially regulated lncRNAs (blue) with their DNA binding sites.
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Allen Institute for Brain Science allen human brain atlas microarray transcriptomic data
( A ) PCA of global <t>transcriptomic</t> differences. ( B ) Heatmap of globally DEGs when modeled as ~ PDX_ID + RTS. ( C ) Volcano plot of globally DEGs when modeled by ~RTS alone (red text meets cutoffs of log 2 fold change > 2 or < –2, adjusted P < 0.05). ( D ) Circos plot of differentially regulated lncRNAs (red) with their direct DNA binding targets (black) and differentially regulated lncRNAs (blue) with their DNA binding sites.
Allen Human Brain Atlas Microarray Transcriptomic Data, supplied by Allen Institute for Brain Science, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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( A ) PCA of global transcriptomic differences. ( B ) Heatmap of globally DEGs when modeled as ~ PDX_ID + RTS. ( C ) Volcano plot of globally DEGs when modeled by ~RTS alone (red text meets cutoffs of log 2 fold change > 2 or < –2, adjusted P < 0.05). ( D ) Circos plot of differentially regulated lncRNAs (red) with their direct DNA binding targets (black) and differentially regulated lncRNAs (blue) with their DNA binding sites.

Journal: JCI Insight

Article Title: An in vivo model of glioblastoma radiation resistance identifies long noncoding RNAs and targetable kinases

doi: 10.1172/jci.insight.148717

Figure Lengend Snippet: ( A ) PCA of global transcriptomic differences. ( B ) Heatmap of globally DEGs when modeled as ~ PDX_ID + RTS. ( C ) Volcano plot of globally DEGs when modeled by ~RTS alone (red text meets cutoffs of log 2 fold change > 2 or < –2, adjusted P < 0.05). ( D ) Circos plot of differentially regulated lncRNAs (red) with their direct DNA binding targets (black) and differentially regulated lncRNAs (blue) with their DNA binding sites.

Article Snippet: Of these, existing Affymetrix transcriptomic microarray data were available for 13 PDX lines ( n = 7 sensitive, n = 6 resistant).

Techniques: Binding Assay